Changing Healthcare Worldwide

Optimizing pain management

Diclofenac Sodium is a member of the class of drugs known as Non-Steroidal Anti-Inflammatory Drugs or NSAIDs for short. This class includes Aspirin, Ibuprofen (Advil®), Naproxen Sodium (Aleve®) and Indomethacin (Artracin®). The class provides analgesic and antipyretic (fever-reducing) effects, and, in higher doses, anti-inflammatory effects. 

Diclofenac is the active ingredient in the newly introduced and widely prescribed Volatren® Gel. While Diclofenac is a potent analgesic and anti-inflammatory, the gel delivery vehicle is a weak performer in delivering the drug. Diclofenac is typically unstable in ethanol solutions so until now only very low concentrations could be achieved. 

The TDSC system renders Diclofenac stable in solution with no degradation products. Doses as high a 5% (50 mgs) are achievable and a 0.2% (2mgs) dose should compare favorably to a 25 mg oral dose. Orally-dosed Diclofenac is often a stomach irritant and can only be taken for short stints. An effective smaller dose would be well-tolerated over a longer period.

TDSC is developing protocols and study plans for a Diclofenac Sodium product with the Anaesthesia Laboratory at Barts and the London NHS.